(122) S100B Single Nucleotide Polymorphisms and Haplotypes Associate with Both  Acute Crisis Pain and Chronic Pain in Sickle Cell Disease

In this study, we examine the influence of single nucleotide polymorphisms (SNP) in the S100B gene on acute and chronic pain variation in SCD. 136 subjects with SCD recorded their baseline, non-crisis pain experience on a digital version of the McGill Pain Questionnaire, from which we obtained composite pain index (CPI) scores as a measurement for chronic pain. Utilization of emergency or urgent care owing to painful crisis was recorded as a marker for acute pain.

Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: N. Sadhu, E. Jhun, Y. Yao, Y. He, D. Wilkie, R. Molokie, Z. Wang Source Type: research