Updates in Parkinson's, Myasthenia Gravis, and Multiple Sclerosis Updates in Parkinson's, Myasthenia Gravis, and Multiple Sclerosis

New studies in neurology: Dr Christoph Diener discusses recent developments in the field.Medscape Neurology
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery Commentary Source Type: news

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ConclusionsPatients with PD and LIDs have abnormal cortical facilitation, possibly suggesting overactive glutamatergic neurotransmission in specific circuits within M1. Although not responsive to l-dopa, this dysfunction is restored by the anti-glutamatergic properties of safinamide 100 mg. The results suggest that the abnormal cortical facilitation in M1 contributes to the pathophysiology of LIDs.
Source: Brain Stimulation - Category: Neurology Source Type: research
The novel drug for relapsing multiple sclerosis is designed to reduce gastrointestinal events compared to dimethyl fumarate.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
This cohort study compares long-term information-processing efficiency between patients with pediatric-onset and adult-onset multiple sclerosis in Sweden.
Source: JAMA Neurology - Category: Neurology Source Type: research
In this issue ofJAMA Neurology, McKay and colleagues found that adults with pediatric-onset multiple sclerosis (POMS) vs those with adult-onset MS (AOMS) performed more slowly on a widely used cognitive screening measure that tests information-processing speed. Patients were drawn from a Swedish nationwide cohort of 5704 adults with definite MS, of whom 300 had POMS. The Symbol Digit Modalities Test (SDMT) was serially administered during neurology visits. Early in their course, those with POMS performed somewhat better than those with AOMS. However, the 2 groups diverged by the time the POMS patients reached 30 years of a...
Source: JAMA Neurology - Category: Neurology Source Type: research
Several autoimmune diseases including multiple sclerosis (MS) cause increased transcription of endogenous retroviruses (HERVs) normally repressed by heterochromatin. In parallel, HERV-derived sequences were reported to drive gene expression. Here, we have examined a possible link between promoter and enhancer divergent transcription and the production of HERV transcripts. We find that HERV-derived sequences are in general counter-selected at regulatory regions, a counter-selection that is strongest in brain tissues while very moderate in stem cells. By exposing T cells to the pesticide dieldrin, we further found that a ser...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Chromatin, Epigenetics, Genomics & Functional Genomics, Molecular Biology of Disease Articles Source Type: research
Source: International Journal of Neuroscience - Category: Neuroscience Authors: Source Type: research
Authors: Cichos KH, Lehtonen EJ, McGwin G, Ponce BA, Ghanem ES Abstract INTRODUCTION: Orthopaedic surgeons are wary of patients with neuromuscular (NM) diseases as a result of perceived poor outcomes and lack of data regarding complication risks. We determined the prevalence of patients with NM disease undergoing total joint arthroplasty (TJA) and characterized its relationship with in-hospital complications, prolonged length of stay, and total charges. METHODS: Data from the Nationwide Inpatient Sample from 2005 to 2014 was used for this retrospective cohort study to identify 8,028,435 discharges with total jo...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
This article is protected by copyright. All rights reserved. PMID: 29159928 [PubMed - as supplied by publisher]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research
ConclusionsUsing real‐world data, we obtained up‐to‐date prevalence, treatment status and medical cost information for MS in Japan. The present results showed the efficacy of a real‐world database to obtain the latest national trends for rare diseases, such as MS; this could have important implications for clinicians and policymakers. Comparison of the medical costs per patient per month (PPPM, upper) and per member per month (PMPM, below) of multiple sclerosis with those of similar immune or neurodegenerative diseases in Japan. Although the cost PPPM for MS was higher than the costs for Parkinson's disease and rh...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: Original Article Source Type: research
AbstractPurposeThe aim of this study was to develop a Korean version of the Stigma Scale for Chronic Illness 8-items (SSCI-8) and then assess its reliability and construct validity among patients with neurological conditions.MethodPatients diagnosed with stroke, Parkinson ’s disease, epilepsy, multiple sclerosis, myasthenia gravis, and amyotrophic lateral sclerosis were recruited. Reliability was assessed for internal consistency with Cronbach’s alpha coefficient. Exploratory factor analysis (EFA) was used to extract potential factors of Korean SSCI-8. Convergent validity was assessed by correlating scores on t...
Source: International Journal of Behavioral Medicine - Category: Psychiatry Source Type: research
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