The potential of actigraphy to assess agitation in dementia

It is now well understood that much of the public health burden of dementia is due to neuropsychiatric symptoms, including agitation, apathy, and circadian rhythm disturbances. Improving interventions for these targets are crucial to decreasing patient and caregiver distress. There have been recent successes in repurposing existing medications for these targets including agitation, for example citalopram 1. But treatment development requires reliable measures and to date most agitation measures are largely subjective, consisting of informant reports with anchored ordinal scales.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Invited Perspective Source Type: research

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CONCLUSIONS: CES-D is a valid and reliable scale for detecting caregiver depression in dementia. It has added utility, beyond that of a caregiver burden scale, in identifying a subgroup of caregivers with depression but not burden. However, two subscales (Positive affect and Interpersonal problems) may require caution in interpretation among non-Caucasian caregivers. PMID: 31307034 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
CONCLUSIONS: Amyloid-PET positivity is associated with lower MoCA scores. Clinical utility of amyloid-PET scan is likely to be suboptimal at the MoCA score cutoff for minimal cognitive impairment. PMID: 31305321 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Authors: Kapasi A, Yu L, Stewart CC, Schneider JA, Bennett DA, Boyle PA Abstract BACKGROUND: Low health and financial literacy may be an early behavioral manifestation of cognitive impairment, dementia, and accumulating Alzheimer pathology. However, there are limited studies investigating the behavioral features associated with hyperphosphorylated transactive response DNA-binding protein-43 (TDP-43), a common age-related pathology, and even fewer studies investigating the neurobiological basis underlying low literacy in aging. OBJECTIVE: To test the hypothesis that TDP-43 pathology is associated with lower lite...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Protein tau may spread more rapidly in female brains than males ’, adding to range of factorsThe reason women appear to be at greater risk of developing Alzheimer ’s disease than men might be due to a number of genetic, anatomical and even social influences, researchers have suggested.Recent figures show about 65% of those with living with dementia in the UK are women, with a similar statistic seen in the US for Alzheimer ’s disease, while dementia is theleading cause of death for women in England. Alzheimer ’s disease is only one of the types of dementia, but the most common form.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Alzheimer's Science Society Health Dementia Source Type: news
In this study, we aimed to investigate correlated structural and functional brain changes in AD and BD by combining resting-state functional magnetic resonance imaging (fMRI) and diffusion MRI. A group independent component analysis was first performed on the fMRI data to extract 49 intrinsic connectivity networks (ICNs). Then we conducted a multi-set canonical correlation analysis on three features, functional network connectivity (FNC) between ICNs, fractional anisotropy (FA) and mean diffusivity (MD). Two inter-correlated components show significant group differences. The first component demonstrates distinct brain chan...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
New research gives some biological clues to why women may be more likely than men to develop Alzheimer's disease and how this most common form of dementia varies by sex
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Expression and Purification of Untagged α-Synuclein. Methods Mol Biol. 2019;1948:261-269 Authors: Powers AE, Patel DS Abstract α-Synuclein (αS) is an abundant neuronal protein which has been implicated, among others, in the pathogenesis of neurodegenerative diseases like Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In fact, αS is the major constituent of Lewy bodies, the primarily proteinaceous inclusions found in the nervous tissue of PD and DLB patients. While its physiological role is unclear, it is believed to be involved in the regulation of synaptic vesic...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
People living with dementia should be offered activities such as exercise, aromatherapy, art, gardening, baking, reminiscence therapy, music therapy, mindfulness and animal assisted therapy to help promote their wellbeing. The recommendation comes in NICE's updated quality standard on dementia published 28 June 2019. It says people living with dementia and people involved in their care should be given the opportunity to talk about their life experiences, preferences, interests, strengths with a healthcare professional. This can help the person living with dementia to choose activities to promote wellbeing that suit their p...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
(Vanderbilt University Medical Center) In a new study published in the Journal of Gerontological Nursing, Prusaczyk and colleagues showed that older patients with dementia at one major teaching hospital were less often provided with transitional care steps including patient education, discharge planning, and documentation of medication history, as compared to patients without dementia.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Regardless of how much genetic risk someone has, a good diet, adequate exercise, limiting alcohol and not smoking made dementia less likely
Source: Health News: - Category: Consumer Health News Source Type: news
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