Development of a Novel Liquid Chromatography-Tandem Mass Spectrometric Method for Aristolochic Acids Detection: Application in Food and Agricultural Soil Analyses

We report the development of a novel liquid chromatography-tandem mass spectrometry (LC−MS/MS) method for AA-detection. One striking feature of the method is that the Zn/H+-induced nitroreduction convert AA into their respective aristolactams, which dramatically enhances their analytical sensitivity. The method was applied to quantitate AA in food grains and soil samples collected from farming villages of Serbia, and flour samples purchased from supermarkets. To the best of our knowledge, this is the first report of detecting AA in food ingredients available in supermarkets, which is alarming because it reveals AA poses insidious threats not only to residents of rural farming villages, but also to people residing in urban areas.
Source: Food Chemistry - Category: Food Science Source Type: research