Prognostic Significance of Mesenchymal Cell Colony Forming Units in Bronchoalveolar Lavage Fluid for Restrictive Chronic Lung Allograft Dysfunction

Restrictive chronic lung allograft dysfunction (rCLAD) is associated with decreased survival but individual prognosis remains variable. Increased numbers of colony-forming units (CFU) of mesenchymal stromal cells (MSC) —the effector cells in fibroproliferation—derived from bronchoalveolar lavage (BAL) fluid have been associated with developing bronchiolitis obliterans syndrome (BOS). However, the prognostic significance of MSC in rCLAD is unknown.

Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M.P. Combs, M. Xia, D.S. Wheeler, E.A. Belloli, D.M. Lyu, N.M. Walker, S. Murray, V.N. Lama Tags: 46 Source Type: research