Effects of Nissen Fundoplication on Markers of Microaspiration and Inflammation after Lung Transplantation

Gastroesophageal reflux disease (GERD) is prevalent after lung transplantation (LTx) and has been associated with allograft injury and chronic lung allograft dysfunction (CLAD) presumably through chronic microaspiration of bile acids and other gastric contents with subsequent innate immune activation. Anti-reflux surgery is widely used at some centers to treat GERD in LTx; however, its role in inflammation or aspiration is unknown. Our objective was to examine the effects of early anti-GERD surgery in LTx recipients on markers of microaspiration and inflammation in the bronchoalveolar lavage (BAL).

Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: K.C. Zhang, S.E. Hunter, E. Huszti, M. Ahmed, L. Levy, K.M. Boonstra, A.T. Sage, S. Azad, R. Zamel, C. Frankel, M. Budev, P. Shah, L.D. Snyder, J. Belperio, L.G. Singer, S.S. Weigt, J.L. Todd, S. Keshavjee, S.M. Palmer, T. Martinu, for the CTOT-20 Investi Tags: 157 Source Type: research