Exploration of TiO2 nanoparticle mediated microdynamic therapy on Cancer treatment

Publication date: Available online 14 March 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Xiao Chu, Liang Mao, Omar Johnson, Kang Li, Jonathan Phan, Qingshui Yin, Lihua Li, Junying Zhang, Wei Chen, Yu ZhangAbstractRadical therapy takes advantage of the reactive oxygen species produced in greater quantities within tumor cells than in normal cells. Here, for the first time, we explore a TiO2 nanoparticle mediated microwave induced radical therapy (termed as Microdynamic Therapy) as a new cancer treatment method. The experiments in vitro and in vivo demonstrate that colloidal TiO2 nanoparticles could significantly suppress the growth of osteosarcomas, even under low power (5 W) microwave (MW) irradiation for 5 min. The high photocatalytic activity of TiO2 nanoparticles efficiently utilizes the microwave-induced plasmonic effect for the formation of reactive oxygen species (ROS). Furthermore, TiO2 nanoparticles exhibit a higher cytotoxicity on cancer cells (osteosarcoma UMR-106 cells) than on normal cells (mouse fibroblast L929 cells). The effectiveness of TiO2 nanoparticles for microwave induced radical therapy demonstrates that this is a new landmark approach to treating cancers.Graphical AbstractA new trend for cancer therapeutics is to design and develop drugs that exploit the microenvironment and metabolism of malignant tumors. Radical therapy takes advantage of the reactive oxygen species produced in greater quantities within the tumor c...

Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 15, 2019 Category: Nanotechnology Source Type: research