Self-assembly of chlorin-e6 on γ-Fe2O3 nanoparticles: Application for larvicidal activity against Aedes aegypti

Publication date: Available online 13 March 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Massimiliano Magro, Simone Bramuzzo, Davide Baratella, Juri Ugolotti, Giorgio Zoppellaro, Giulia Chemello, Ike Olivotto, Cristina Ballarin, Giuseppe Radaelli, Beatrice Arcaro, Marco De Liguoro, Olimpia Coppellotti, Laura Guidolin, Jessica de Almeida Roger, Emanuela Bonaiuto, Radek Zboril, Fabio VianelloAbstractAedes aegypti mosquitos are widespread vectors of several diseases and their control is of primary importance for biological and environmental reasons, and novel safe insecticides are highly desirable. An eco-friendly photosensitizing magnetic nanocarrier with larvicidal effects on Aedes aegypti was proposed. The innovative core-shell hybrid nanomaterial was synthesized by combining peculiar magnetic nanoparticles (called Surface Active Maghemite Nanoparticles - SAMNs, the core) and chlorin-e6 as photosensitizer (constituting the shell) via self-assembly in water. The hybrid nanomaterial (SAMN@chlorin) was extensively characterized and tested for the photocidal activity on larvae of Aedes aegypti. The SAMN@chlorin core-shell nanohybrid did not present any toxic effect in the dark, but, upon light exposure, showed a higher photocidal activity than free chlorin–e6. Moreover, the eco-toxicity of SAMN@chlorin was determined in adults and neonates of Daphnia magna, where delayed toxicity was observed only after prolonged (≥4 h) exposure to intense lig...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research