Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum.

DISCUSSION: Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker. PMID: 30853464 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30853464?dopt=Abstract

Source: The Journal of Alzheimers Association - March 13, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research