Inheritance of imbalances in the recurrent chromosomal translocation t(11;22) in female and male carriers: Clarification by using combined PGD and sperm FISH analysis

Conclusion(s)Genetic counselling must take into consideration the risk of a birth related to the adjacent-1 segregation mode, irrespective the translocation carrier sex. These results will allow a deeper understanding of the PGD results of t(11;22) carriers, which often include a high number of aneuploid embryos.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research