Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer.

This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-β) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-β signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions. PMID: 30836770 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30836770?dopt=Abstract

Source: Cancer Investigation - March 8, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research