Heart-kidney interactions: mechanistic insights from animal models.

Heart-kidney interactions: mechanistic insights from animal models.
Am J Physiol Renal Physiol. 2019 Mar 06;:
Authors: Liu S
Abstract
Pathological changes in heart or kidney can instigate the release of a cascade of cardiorenal mediators that promote injury in the other organ. Combined dysfunction of heart and kidney is referred to as cardiorenal syndrome and gained considerable attention. Cardiorenal syndrome has been classified into 5 distinct entities, each with different major pathophysiological changes. Despite the magnitude of the public health problem of cardiorenal syndrome, the underlying mechanisms are incompletely understood and effective intervention is unavailable. Animal models allow us to discover pathogenic molecular changes in order to clarify the pathophysiological mechanisms responsible for heart-kidney interactions and enable more accurate risk stratification and effective intervention. Herein, this article focuses on the use of currently available animal models to elucidate mechanistic insights in clinical cardiorenal phenotype arising from primary cardiac injury, primary renal disease with special emphasis of chronic kidney disease-specific risk factors, and simultaneous cardiorenal/renocardiac dysfunction. The development of novel animal models that recapitulate more closely the cardiorenal phenotype in clinical scenario and discover molecular basis of this condition will be of great benefits.
PMID: 308...

Source: American Journal of Physiology. Renal Physiology - March 5, 2019 Category: Physiology Authors: Liu S Tags: Am J Physiol Renal Physiol Source Type: research