Prevalence of Germline Mutations in Polyposis and Colorectal Cancer –Associated Genes in Patients With Multiple Colorectal Polyps

Guidelines recommend genetic testing of patients with 10 or more cumulative adenomatous polyps. However, little is known about the utility of these tests —especially for older patients. We aimed to determine the prevalence of pathogenic mutations in patients with multiple colorectal polyps, stratified by age.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research

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Hyperplastic polyps, once thought to have a benign course, are now part of a larger heterogeneous group known as serrated polyps, which include hyperplastic polyps (HPs), sessile serrated polyps (SSPs), and traditional serrated adenomas (TSAs). The latter group, once known as serrated adenomas, are relatively rare, accounting for less than 5% of all serrated polyps. Thus, it is not surprising that less is known about these lesions than about conventional adenomas or even SSPs. Because these lesions have dysplasia and can progress to colorectal cancer (CRC), more data regarding prevalence and risk factors TSAs are vital.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
ConclusionsIn contrast to CRC screening, this first study in CRC post-operative surveillance patients demonstrates a preference for OC. Assuming patient preference is an important determinant, introduction of CTC as a method to increase patient adherence with CRC surveillance is unlikely to be effective.Trial registrationClinical registration number: NCT02143115.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
AbstractA 37-year-old male with tarry stool presented to our hospital. Esophagogastroduodenoscopy revealed advanced gastric cancer, fundic gland polyposis (FGPsis), and negativity forHelicobacter pylori (HP) infection. Computed tomography exhibited multiple liver tumors. Total colonoscopy (TCS) demonstrated 139 tubular adenomas. He was diagnosed as having unresectable gastric cancer and received systemic chemotherapy. His sister and mother had colorectal adenomatous polyposis as revealed by TCS. His sister had FGPsis and was negative forHP infection, whereas his mother had early gastric cancer withHP infection but not FGPs...
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
This study follows patients with negative CTC results to evaluate the number of clinically significant lesions that may have been potentially missed by CTC.
Source: Canadian Association of Radiologists Journal - Category: Radiology Authors: Tags: Abdominal Imaging / Imagerie abdominale Source Type: research
Authors: Lund M, Erichsen R, Njor SH, Laurberg S, Valori R, Andersen B Abstract Objective: Cecal intubation rate (CIR) is known to be inversely associated with interval colorectal cancer (CRC) risk. Cecal intubation may be achieved by the use of force and sedation jeopardizing patient safety. The Performance Indicator of Colonic Intubation (PICI) is defined as the proportion of colonoscopies achieving cecal intubation with use of ≤2 mg midazolam and no-mild patient-experienced discomfort. We aimed (i) to measure the variation of PICI between colonoscopists and colonoscopy units; (ii) to assess the correla...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
CONCLUSIONS.—: Poor prognostic factors for malignant polyps include high tumor grade, presence of lymphovascular invasion, tumor less than 1 mm from resection margin, submucosal invasion deeper than 1 mm, and high tumor budding. These features should be assessed by the pathologist and communicated to the clinical team in order to allow proper management. PMID: 31509454 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - Category: Laboratory Medicine Authors: Tags: Arch Pathol Lab Med Source Type: research
Publication date: Available online 6 September 2019Source: Pharmacological ResearchAuthor(s): Imran Khan, Guoxin Huang, Xiao-ang Li, Weilin Liao, Wai Kit Leong, Wenrui Xia, Xiqing Bian, Jianlin Wu, W.L. Wendy HsiaoAbstractThe incidence of colorectal cancer (CRC) is alarming among younger peoples. While no effective chemopreventive drug available in the market, researchers have been searching for alternative strategies against CRC that are in demand. Therefore, we tested the cancer-preventive properties of Ganoderma lucidum (Lingzhi) polysaccharides (GLP), along with the saponins extracted from Gynostemma pentaphyllum (GpS)...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: October 2019Source: Cancer Epidemiology, Volume 62Author(s): Erin Kelty, Sarah V Ward, Gemma Cadby, Nina S McCarthy, Peter O’Leary, Eric K Moses, Hooi C. Ee, David B. PreenAbstractAimsThe aim of this study was to examine factors including family history, medical history and comorbidities associated with the risk of colorectal cancer (CRC) in young (18–49 years) and middle-age (50–69 years) individuals.MethodsState records were used to identify individuals born in Western Australia between 1945 and 1996, and their first-degree relatives. Individuals in the cohort and their relatives were ...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
New research finds that exercising daily in adolescence and adulthood reduces the risk of developing adenomatous polyps at an older age.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Colorectal Cancer Source Type: news
This study sought to determine the feasibility of using red cell distribution width-to-lymphocyte ratio (RLR) as a tool to facilitate CRC detection. Methods: Seventy-eight healthy controls, 162 patients diagnosed with CRC, and 94 patients with colorectal polyps (CP) from June 2017 to October 2018 were retrospectively reviewed. Clinical data were obtained to analyze preoperative RLR level, and receiver operating characteristic (ROC) curve analysis was performed to estimate the potential role of RLR as a CRC biomarker. Results: RLR was higher in patients with CRC than in healthy participants (P
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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