Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline.

Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline.
Alzheimers Dement. 2019 Feb 25;:
Authors: Zhang F, Zhong R, Li S, Fu Z, Wang R, Wang T, Huang Z, Le W
Abstract
OBJECTIVE: The present work aims to evaluate the significance of sleep disturbance and electroencephalogram (EEG) alteration in the early stage of Alzheimer's disease (AD).
BACKGROUND AND RATIONALE: Sleep disturbance is common in patients with AD. It is not known if it can occur at the early stage of AD and if EEG recording may help identify the early sign of the disease.
HISTORICAL EVOLUTION: Sleep disturbance in AD has generally been considered as late consequence of the neurodegenerative process. A growing body of evidence has suggested that the sleep disturbance may occur at the early stage of AD.
UPDATED HYPOTHESIS: Based on the previous epidemiologic studies and our recent findings, we propose that sleep disturbance may play an important role in the development of AD. Sleep EEG changes may serve as a valuable early sign for AD in the prepathological stage.
EARLY EXPERIMENTAL DATA: Our data suggested that AβPPswe/PS1ΔE9 transgenic AD mice at preplaque stage (3 and 4 months of age) exhibited different profile of sleep architecture and sleep EEG, which preceded the cognitive deficit and AD neuropathology.
FUTURE EXPERIMENTS AND V...

Source: The Journal of Alzheimers Association - March 4, 2019 Category: Psychiatry Tags: Alzheimers Dement Source Type: research