Fibroblasts Prompt Tumors to Mobilize Their Glycogen Reserves.

Fibroblasts Prompt Tumors to Mobilize Their Glycogen Reserves. Trends Cell Biol. 2019 Feb 27;: Authors: Coller HA Abstract Cancer cells use multiple strategies to fuel their unchecked growth. Inarecent paper, Curtis etal.(CellMetab. 2019;29:141-155) delineate a novel strategy whereby cancer-associated fibroblasts (CAFs) secrete cytokines that stimulate glycogen breakdown in ovarian cancer cells. CAF-induced glycogen breakdown increases glycolysis and ATP generation, and facilitates proliferation and metastasis. PMID: 30826215 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30826215?dopt=Abstract

Source: Trends in Cell Biology - February 26, 2019 Category: Cytology Authors: Coller HA Tags: Trends Cell Biol Source Type: research