Tissue and Exosomal Serine Protease Inhibitors Are Significantly Overexpressed in Chronic Rhinosinusitis With Nasal Polyps.

CONCLUSION: Our analysis supported that protease inhibitors of the fibrinolysis pathway, especially SerpinB2, SerpinF2, and SerpinG1, are highly deranged in patients with CRSwNP. These findings suggest a downregulation of the fibrinolysis pathway via proteolytic cascade imbalance leading to excessive polyp fibrin deposition. Our data further supported our hypothesis that exosomal proteomic analyses may be used as noninvasive "liquid biopsy" for CRSwNP and a novel method to study chronic sinonasal inflammation. PMID: 30810048 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30810048?dopt=Abstract

Source: American Journal of Rhinology and Allergy - February 27, 2019 Category: ENT & OMF Authors: Mueller SK, Nocera AL, Dillon ST, Libermann TA, Wendler O, Bleier BS Tags: Am J Rhinol Allergy Source Type: research