[Undifferentiated Carcinoma of the Nasopharynx in Dakar, an Area Supposed to be Non-Endemic: about 13 Cases].

[Undifferentiated Carcinoma of the Nasopharynx in Dakar, an Area Supposed to be Non-Endemic: about 13 Cases]. Bull Soc Pathol Exot. 2018;111(2):84-89 Authors: Gaye AM, Mouamba FG, Diemé MJ, Niang D, Thiam I, Dial CMM Abstract Undifferentiated carcinoma of the nasopharynx (UCNT) has variable incidence throughout the world. Senegal is supposed to be a non-endemic zone. There is a constant connection with the Epstein-Barr virus. In this work, the authors study and discuss the pathological aspects of undifferentiated carcinoma of the nasopharynx in 13 cases. They also seek to make the link between this cancer and the presence of an Epstein-Barr virus infection in these patients. This is a retrospective series of cases involving patients with UCNT, diagnosed on histological basis in Dakar and confirmed by immunohistochemistry. An EBV search was performed on these cases through in situ hybridization by the EBER probe. 15 cases diagnosed on histological basis were able to benefit from immunohistochemistry, and 13 cases were confirmed, ie 87%. The mean age was 28.37 years with extremes of 5 and 56 years. The male sex predominated, with a sex ratio of 8/3. The macroscopic lesions were of ulcerous-budding type for cases revealed by a mass of the cavum. The histological aspect resulted in a proliferation of atypical undifferentiated cells, with large, clear, strongly nucleated nuclei, with eosinophilic cytoplasm, scarcely abundant. The stroma ...
Source: Bulletin de la Societe de Pathologie Exotique - Category: Tropical Medicine Tags: Bull Soc Pathol Exot Source Type: research