Clinical Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody Neuromyelitis Optica Spectrum Disorder.

We describe their epidemiological and clinical features.ResultsTwenty-three patients were included in the study with a female to male ratio of 2.3:1. The mean age of the cohort was 42.6 years, while the mean age at onset was 37 years. The most frequent initial presentation was optic neuritis, followed by ADEM-like encephalopathic clinical picture and transverse myelitis. Five patients showed a monophasic disease course while the rest experienced a relapsing phenotype. Nine patients (39%) experienced immediate relapses on withdrawal of steroids.conclusions. Our cohort showed clinical characteristics comparable with previously published reports of MOG antibody disease worldwide. Unique features of MOG antibody disease are: high frequency of optic neuritis attacks, good long term neurological recovery and sensitivity to steroid use and withdrawal.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research