Viruses, Vol. 11, Pages 176: Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry

Viruses, Vol. 11, Pages 176: Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry Viruses doi: 10.3390/v11020176 Authors: Michela Mazzon Ana Maria Ortega-Prieto Douglas Imrie Christin Luft Lena Hess Stephanie Czieso Joe Grove Jessica Katy Skelton Laura Farleigh Joachim J. Bugert Edward Wright Nigel Temperton Richard Angell Sally Oxenford Michael Jacobs Robin Ketteler Marcus Dorner Mark Marsh Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made available. Broad-spectrum antivirals are drugs with the potential to inhibit infection by viruses from different groups or families, which may be deployed during outbreaks when specific diagnostics, vaccines or directly acting antivirals are not available. While pathogen-directed approaches are generally effective against a few closely related viruses, targeting cellular pathways used by multiple viral agents can have broad-spectrum efficacy. Virus entry, particularly clathrin-mediated endocytosis, constitutes an attractive target as it is used by many viruses. Using a phenotypic screening strategy where the inhibitory activity of small molecules was sequentially tested against different viruses, we identified 12 compounds with broad-spectrum activity, and found a subset blockin...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research

Related Links:

Date: Tuesday, 09 24, 2019; Speaker: Dr. Rachel Abrams, NINDS; Dr. Avi Nath, NINDS; Building: Building 10 (Clinical Center); Lipsett Auditorium; CME Credit
Source: NIH Calendar of Events - Category: American Health Source Type: events
Conclusion: Our findings revealed that oral immunization with V. cholerae OMVs might induce a long-term immunity, especially when administered in combination with KWC. This study tested the adjuvant activity of OMVs and may be useful in future nano vaccine research. PMID: 31523404 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
Conclusion: More studies need to be conducted on the frequency of all other virulence factors among these isolates, which can provide basic information for improvement or substitution of current vaccinal strains. Overall, as the new designed sets of primers showed more potential in detecting the corresponded genes, researchers can consider them in further studies. PMID: 31523401 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
In this study, we analyzed the codon usage pattern of the S gene using complete coding sequences and complete PDCoV genomes to gain a deeper understanding of their genetic relationships and evolutionary history. We found that during evolution three groups evolved with a relatively low codon usage bias (effective number of codons (ENC) of 52). The factors driving bias were complex. However, the primary element influencing the codon bias of PDCoVs was natural selection. Our results revealed that different natural environments may have a significant impact on the genetic characteristics of the strains. In the future, more epi...
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Authors: Housset B Abstract Vaccines have saved millions of lives and reduced the severity of many infections. A reduction in vaccination coverage is now reflected in the re-emergence of epidemics of mumps, pertussis, measles and chickenpox. Many people do not recognize the effectiveness of vaccination and fear the side effects. The main concern is the safety of vaccines. Lack of information weighs less than lack of trust in health authorities. The greater responsibility of the individual and the respect for his free will, may lead the authorities to a less vigourous promotion of the "vaccination duty" wh...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
CONCLUSION: Anti-vaccine ideas were born with vaccines; they are abundantly spread through the Internet and social networks and can give a false impression of their basis in reality. It is time for positive action not merely a defensive approach. PMID: 31522949 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Authors: Autran B Abstract The aging population raises a number of public health issues including a need to address the severity and frequency of infections observed in older people. Vaccines play an important role in prevention. However, immunosenescence alters the intensity and quality of vaccine responses, thus limiting the impact of recommendations directed after 65 years for vaccination against flu, pneumococci, pertussis, tetanus and zoster. Immunosenescence, aggravated by co-morbidities, varies with age, becoming apparent after 60-65 years and more profound after 85 years. All stages of vaccine responses are...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Adriano Queiroz1, Isabella Fernanda Dantas Pinto2, Maricélia Lima3, Marta Giovanetti1,4, Jaqueline Goes de Jesus1, Joilson Xavier1, Fernanda Khouri Barreto5, Gisele André Baptista Canuto6, Helineide Ramos do Amaral7, Ana Maria Bispo de Filippis4, Denise Lima Mascarenhas8, Melissa Barreto Falcão8, Normeide Pedreira Santos8, Vasco Ariston de Carvalho Azevedo9, Marcos Yukio Yoshinaga2*, Sayuri Miyamoto2 and Luiz Carlos Junior Alcantara1,4,10* 1Laboratório de Patologia Experimental, Instituto Gonçalo Moniz, Salvador, Brazil 2Departamento de Bioquímica, Instituto de Quími...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
DAVID E. BLOOM is the Clarence James Gamble Professor of Economics and Demography, DANIEL CADARETTE is a research assistant, and JP SEVILLA is a research associate, all at Harvard University’s T.H. Chan School of Public Health.By David E. Bloom, Daniel Cadarette and JP SevillaWASHINGTON DC, Jul 3 2018 (IPS)Infectious diseases and associated mortality have abated, but they remain a significant threat throughout the world.We continue to fight both old pathogens, such as the plague, that have troubled humanity for millennia and new pathogens, such as human immunodeficiency virus (HIV), that have mutated or spilled over ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Active Citizens Development & Aid Economy & Trade Global Headlines Health TerraViva United Nations Source Type: news
CONCLUSIONS The urge to do something to help in an international medical crisis is understandable and admirable, but the adverse impacts reported by participants here – at every stage of deployment, suggest that preparedness for these missions needs improvement and at the very least, high risk missions should be limited to more seasoned and well trained (for conditions in the field) personnel. While volunteering for a medical mission during a health crisis can be very rewarding, both professionally and personally, it can also be very disruptive and impactful. All volunteers for high risk missions must be made fully a...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
More News: Chikungunya | Ebola | Ebola Vaccine | Epidemics | Epidemiology | Influenza | Influenza Vaccine | Outbreaks | Vaccines | Virology | Zika Virus