Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta ‐analysis

This is so far the most comprehensive evidence ‐based meta‐analysis on PLCE1 rs2274223 variant and digestive tract cancer. Our findings indicated that the PLCE1 rs2274223 variant might serve as a potential biological marker of esophageal and gastric cancer in East Asians. Future investigations are needed to explore potential roles of PLCE1 r s2274223 variant in the development of other types of cancer. AbstractBackgroundThe relationship between phospholipase C ε‐1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta ‐analysis to obtain a more credible conclusion.MethodsPubMed, Medline, and Embase were systematic searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.ResultsA total of 27 studies were finally included. Pooled analyses suggested thatPLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model:p  
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Conclusion: The diagnostic value and prognostic value of significant DEMIs in cancers of the digestive tract were identified, which may provide a novel direction for treatment and prognosis improvement of cancers of the digestive tract. PMID: 31737678 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
MR imaging has been increasingly used in the diagnostic work-up of benign and malignant conditions of the gastroesophageal tract. The use of an adequate MR imaging protocol is crucial, although standardization of imaging studies is still far from being implemented. Research on MR imaging-based biomarkers show promising results in assessing tumor aggressiveness and prognosis, and in the evaluation of response to treatment, both in esophageal and gastric cancers.
Source: Magnetic Resonance Imaging Clinics of North America - Category: Radiology Authors: Source Type: research
We conducted risk analyses using the competing risk regression model, which defined death and the development of second malignancies as competing risks. Our study revealed that risk of second primary malignancies was significantly higher compared with the general population. Age, clinical stage, and tumor location were identified as significant factors for the development of second primary malignancies. AbstractBackgroundEsophageal cancer is associated with synchronous or metachronous cancer at other primary sites. However, few studies have evaluated the second malignancies after the treatment of esophageal cancer. The pre...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Abstract SH2B1 is well-known as an adaptor protein, and deletion of SH2B1 results in severe obesity and both leptin and insulin resistance. Some studies have revealed that SH2B1 is involved in the progression of lung cancer, esophageal cancer, gastric cancer, oropharyngeal cancer, and so on. Biological function experiments have proven that SH2B1 can regulate cellular morphology, motility and adhesion by modifying the actin cytoskeletal reorganization, and it can promote cell mitogenesis, transformation, survival and differentiation via different signal pathways by enhancing the kinase activity of several receptor ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
k The Cdx2 homeobox gene is important in assigning positional identity during the finely orchestrated process of embryogenesis. In adults, regenerative responses to tissues damage can require a replay of these same developmental pathways. Errors in reassigning positional identity during regeneration can cause metaplasias—normal tissue arising in an abnormal location—and this in turn, is a well-recognized cancer risk factor. In animal models, a gain of Cdx2 function can elicit a posterior shift in tissue identity, modeling intestinal-type metaplasias of the esophagus (Barrett’s esophagus) a...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
Conditions:   Esophagogastric Cancer;   Esophagus Cancer;   Esophageal Cancer;   Gastric Cancer;   Gastric Adenocarcinoma;   Gastroesophageal Junction Adenocarcinoma;   Gastroesophageal Junction Squamous Cell Carcinoma Interventions:   Drug: 18F-BMS-986229 Injection;   Drug: IV 18F-BMS-986229;   Diagnostic Test: PET/CT Scan Sponsors:   Memorial Sloan Kettering Cancer Center;   Bristol-Myers Squibb Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsEarly feeding and discharge for total or proximal gastrectomy is feasible and safe as long as it is carefully applied to high-risk patients, but we must be aware of the relatively higher readmission rate of this patient group.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Endoscopic resections (ERs) are performed for early (T1) cancers mostly of the esophagus, stomach and colorectum, offering a minimally invasive and tissue-preserving alternative to traditional surgical resection. Proper preparation and handling of these specimens is key to allow accurate histological assessment of parameters which will dictate the curative, or non-curative, nature of the procedure. Many histological features have been identified which correlate with risk of recurrence and/or nodal metastases, thereby dictating the need for further management.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: Gastrointestinal/Hepato-Pancreato-Biliary Pathology Source Type: research
AbstractFor Siewert type II adenocarcinoma of the esophagogastric junction (AEG II), or similar tumors classified as Nishi EG, E=G, GE, the type of surgical resection and reconstruction should be individualized. Criteria for decision making mainly focus on the oral extent of esophageal infiltration, the cT and cN category and the functional status of the patient. For cT1/cT2 adenocarcinomas, which are non-poorly cohesive, intestinal type of Lauren Grading 1 or 2 without clinical signs of lymph node metastasis at the distal stomach, a limited transhiatal proximal gastrectomy with double tract reconstruction is recommended. ...
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
ConclusionsHigher case volume can impact certain measures of quality of care but may not address all care structures necessary for ideal Textbook recovery. Future quality improvement strategies should consider using case-mix adjusted Textbook Outcome rates as a surgical quality metric.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
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