Mucosal RNA and Protein Expression as the next frontier in IBS: abnormal function despite morphologically intact small intestinal Mucosa.

Mucosal RNA and Protein Expression as the next frontier in IBS: abnormal function despite morphologically intact small intestinal Mucosa. Am J Physiol Gastrointest Liver Physiol. 2019 Feb 15;: Authors: Rodino-Janeiro BK, Pardo-Camacho C, Santos J, Martinez C Abstract Irritable bowel syndrome is one of the commonest gastrointestinal disorders. Although long-time considered a pure functional disorder, intense research in past years has rendered a very complex and varied array of observations indicating the presence of structural and molecular abnormalities underlying characteristic motor and sensitive changes and clinical manifestations. Analysis of gene and protein expression in the intestinal mucosa has shed light on the molecular mechanisms implicated in IBS physiopathology. This analysis uncovers constitutive and inductive genetic and epigenetic marks in the small and large intestine that highlight the role of epithelial barrier, immune activation, mucosal processing of foods and toxins, and several new molecular pathways in the origin of IBS. The incorporation of innovative high-throughput techniques into IBS research is beginning to provide new insights into highly structured and interconnected molecular mechanisms modulating gene and protein expression at tissue level. Integration and correlation of these molecular mechanisms with clinical and environmental data applying systems biology/medicine and data mining tools emerges as ...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research