Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells.

CONCLUSIONS: Little is known about miR-200c involvement in regulatory processes. Nano miR-200c affects invasion and migration mechanisms. The expression of encapsulated miR-200c contributes to the inhibition/activation of Kras, EMT, Hippo, regulatory pathways and blockers of metastasis. Delivery of miR-200c increases the expression of miR-29b, an EMY regulator, and miR-1247, an inhibitor of cancer genes, both tumor suppressors involved in lung metastasis. Encapsulated miR-200c act on different proteins that regulates cell cycle pathways. These findings represent a part of a regulatory network providing new insights towards improvement of therapy.
PMID: 30744585 [PubMed - in process]

Source: Clinical Lung Cancer - February 11, 2019 Category: Cancer & Oncology Authors: D'Almeida O, Mothar O, Bondzie EA, Lieumo Y, Tagne L, Gupta S, Volkert T, Levine S, Tagne JB Tags: BMC Cancer Source Type: research