Non-invasive evaluation of the relationship between electrical and structural cardiac abnormalities in patients with myotonic dystrophy type 1

ConclusionMyocardial abnormalities depicted by non-ischemic LGE-CMR were the only independent predictor for the occurrence of Afib/Afl on ECG monitoring, previously shown to predict adverse cardiac events in MD1.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research

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The FDA has denied Sarepta Therapeutics ’ application for its second Duchenne muscular dystrophy treatment, despite the company producing twice the amount of data behind its controversial first product approval in 2016. Sarepta (Nasdaq: SRPT) had hoped to launch a treatment called golodirsen that would have doubled its reach among youn g boys with the disease. The drug, like Sarepta’s sole commercial treatment, was developed to skip over the faulty gene that prevents young boys with the disease…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
The U.S. Food and Drug Administration declined to approve Sarepta Therapeutics Inc's newest treatment for Duchenne muscular dystrophy (DMD), a rare muscle-wasting disorder that mainly affects boys, the company said on Monday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
There is a tough ongoing rivalry between drugs and catheters to conquer the commonest electrical chaos in human heart, namely Atrial fibrillation (AF). Mind you,the confusion about the importance of this arrhythmia is huge and real.Bulk of these episodes are transient , paroxysmal and do not require rigorous management.While stroke prevention seems to be the major aim and target , the real world scenario seems to tell  a different story. The nomenclature conundrum  AF may be classified as many ways a learned cardiologists can think . Often it’s done with reference to etiology, duration , rate, neural (sympa...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Uncategorized ACC AHA ESC guidelines for AF affirm race cabana amiodarone for atrial fibrillation CABANA trial carto pulmonary vein ablations cryo balloon for af ablation heart rhythm society atrial fibrillation guidelines rate vs rhythm c Source Type: blogs
Time limit: 0 Quiz-summary 0 of 20 questions completed Questions: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Information This test series requires login for attempting. You can login easily with your Facebook account (Use the CONNECT WITH icon on the upper part of right sidebar displaying t...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs
Please wait while the activity loads. If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled. If loading fails, click here to try again Click on the 'Start' button to begin the mock test. After answering all questions, click on the 'Get Results' button to display your score and the explanations. There is no time limit for this mock test. Start Congratulations - you have completed DM / DNB Cardiology Entrance Mock Test 7. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rate...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
We described the frequency of significant Holter findings in DMD, the relationship between cardiac function and arrhythmia burden, and the impact of these findings on clinical management. Methods and Results A retrospective review was done of patients with DMD who received a Holter from 2010 to 2014. Clinical and arrhythmic outcomes were analyzed. Patients were classified based on left ventricular ejection fraction (LVEF): ≥55%, 35% to 54% and
Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Arrhythmias, Heart Failure, Diagnostic Testing, Echocardiography, Magnetic Resonance Imaging (MRI) Arrhythmia and Electrophysiology Source Type: research
Abstract Cardiac innervation imaging with 123I-meta-iodobenzylguanidine scintigraphy or 11C-meta-hydroxyephedrine positron emission tomography visualizes and quantifies the activity of the sympathetic nervous system. No other imaging modality is able to stratify this potentially important trigger for various cardiac diseases. Recent literature has focussed mostly on its prognostic ability in heart failure patients, but its use is not limited to heart failure alone. In this review, the literature regarding cardiac innervation imaging in arrhythmia and arrhythmogenic syndromes is discussed, which shows potential for...
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
Epicardial adipose tissue is present in normal healthy individuals. It is a unique fat depot which under physiological conditions plays a cardio- protective role. However epicardial adipose tissue when in excess has been shown to be associated with the prevalence and severity of atrial fibrillation. In arrhythmogenic right ventricular cardiomyopathy and myotonic dystrophy fibro fatty infiltration of the myocardium is associated with ventricular arrhythmias. In the ovine model of ischemic cardiomyopathy the presence of intramyocardial adipose or lipomatous metaplasia has been has been associated with increased propensity to...
Source: Heart Rhythm - Category: Cardiology Authors: Tags: CRV Source Type: research
A 75 year old male with a past medical history of ischemic cardiomyopathy, coronary artery disease, 5 vessel coronary artery bypass graft, multiple percutaneous coronary interventions, and atrial fibrillation presented with dizziness and fatigue secondary to ventricular and supraventricular arrhythmias. He underwent an elective ablation but continued to have ventricular tachycardia (VT) with cardiovascular instability despite antiarrhythmic therapy with multiple agents. The patient continued to develop episodes of VT and an episode of ventricular fibrillation (VF).
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
A 31-year-old man presented to the ED with syncope. He was previously healthy, takes no medications, and had run a marathon the day before. He was riding the light rail home from a baseball game when he developed vague 4/10 epigastric abdominal pain associated with nausea and diaphoresis. He remembers feeling lightheaded and flushed before momentarily passing out. His wife said he became quite pale immediately beforehand. He did not have any headache, chest pain, or shortness of breath before or after the syncopal episode. He has a significant family history of premature coronary artery disease. He had normal vital s...
Source: Spontaneous Circulation - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
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