Chemobrain: How It Happens, and Perhaps How It Can Be Stopped Chemobrain: How It Happens, and Perhaps How It Can Be Stopped

New insights into how chemotherapy affects the brain may lead to ways to treat and maybe even prevent the cognitive impact of cancer drugs.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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This article reviews the role of cancer treatments in cognitive decline of patients with brain metastases: surgery, radiotherapy, chemotherapy, targeted therapies, immunotherapies and hormone therapy. Pathological and molecular mechanisms, as well as future directions for limiting cognitive toxicities are also presented. Other causes of cognitive impairment in this population are discussed in order to refine the benefit-risk balance of each treatment modality. Expert Opinion: Cumulative cognitive toxicity should be taken into account, and tailored to the patient's cognitive risk in the light of the expected survival benefi...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - Category: Cancer & Oncology Source Type: clinical trials
Publication date: Available online 12 February 2019Source: Gynecologic Oncology ReportsAuthor(s): Yingao Zhang, Allison Staley, Katherine Tucker, Leslie H. ClarkAbstractMalignant Brenner tumor (MBTs) is a rare histological subtype of epithelial ovarian cancer, accounting for
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: Available online 10 February 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Xiaojia Ren, Diana Boriero, Luksana Chaiswing, Subbarao Bondada, Daret K. St. Clair, D. Allan ButterfieldAbstractIncreasing numbers of cancer patients survive and live longer than five years after therapy, but very often side effects of cancer treatment arise at same time. One of the side effects, chemotherapy-induced cognitive impairment (CICI), also called “chemobrain” or “chemofog” by patients, brings enormous challenges to cancer survivors following successful che...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP. Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Amanda Thomas, 30, from Charlotte, North Carolina, was diagnosed with a rare, aggressive brain cancer in November 2017 and was told she was not a candidate for surgery or chemotherapy.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Peng L, Fu J, Wang W, Hofman FM, Chen TC, Chen L Abstract There is compelling evidence that brain tumors, particularly glioblastoma multiforme (GBM), harbor a small population of cancer stem cells (CSCs). These CSCs have the ability to undergo self-renewal, initiate tumors in vivo, and are resistant to chemotherapy and radiation therapy. The present study determined the spatial distribution of CSCs within the donated brains of two deceased patients affected by glioblastoma multiforme. The following six grossly visible functional regions were identified: Necrotic tumor, viable solid tumor, infiltrating tumo...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Prostaglandin D2 expression is prognostic in high‑grade serous ovarian cancer. Oncol Rep. 2019 Jan 28;: Authors: Alves MR, Do Amaral NS, Marchi FA, Silva FIB, Da Costa AABA, Carvalho KC, Baiocchi G, Soares FA, De Brot L, Rocha RM Abstract To identify biomarkers that could predict response or lack of response to conventional chemotherapy at the time of diagnosis of high‑grade serous ovarian carcinoma (HGSOC), the present study compared large‑scale gene expression from patients with short or long disease‑free survival times, according to the last cycle of chemotherapy, and validated these fi...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
CONCLUSIONS: Treatment of brain metastases from LCNEC of the lung with SRS was associated with improved survival. For the appropriate patients, upfront treatment of limited brain metastases with SRS may be appropriate. PMID: 30732516 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
ConclusionsSquamous cell carcinoma was identified as a positive predictive factor for achieving pathological complete response. Among patients undergoing lung cancer surgery after induction therapy with pathological complete response, brain metastasis occurred most frequently.
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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