Treatment Strategies for Clozapine-Induced Sialorrhea: A Systematic Review and Meta-analysis

ConclusionClozapine-induced sialorrhea is a potentially serious adverse event. Included studies in this meta-analysis were limited by poor study quality. Diphenhydramine, chlorpheniramine and benzamide derivatives appear to have the best supporting evidence and lowest reported adverse events. Caution should be exercised when using propantheline given its increased risk of constipation.

http://link.springer.com/10.1007/s40263-019-00612-8

Source: CNS Drugs - February 13, 2019 Category: Neurology Source Type: research