Alamandine attenuates arterial remodelling induced by transverse aortic constriction in mice.

Conclusions - Alamandine treatment prevents vascular remodelling after TAC, at least in part, through anti-fibrotic and anti-inflammatory effects. Hence, this work opens new avenues for the use of this heptapeptide also as a therapeutic target for vascular disease.

Source: Clinical Science - February 8, 2019 Category: Biomedical Science Authors: Souza-Neto, F. P. d., Silva, M. M., Santuchi, M. d. C., de Alcantara-Leonidio, T. C., Motta-Santos, D., Oliveira, A., Melo, M. B., Canta, G. N., de Souza, L. E., Irigoyen, M. C., Campagnole-Santos, M. J., Guatimosim, S., Souza dos Santos, R. A., Silva, R. Tags: PublishAheadOfPrint Source Type: research