Lymphoprolipherative skin reactions induced by anti-TNF α: An open question.

We describe 5 patients aged between 25-63 diagnosed with autoimmune disorders (psoriatic arthritis- one patient, Crohn's disease- one patient and ankylosing spondylitis- three patients) who received anti-TNFα agents before the development of a cutaneous lymphoproliferative reaction. Histological and immunophenotypical analysis was typical for mycosis fungoides in all of them. Anti-TNFα agents were stopped with regression of the skin rash. A direct effect of anti-TNFα agents in the development of lymphoproliferative reactions (including MF) is suggested and further analyzed. Treatment cessation can be therapeutic. PMID: 30724650 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research