P146 nod2 is required for recovery against mycobiota-driven intestinal disease and for generation of protective type 1 and 3 host responses

The microbiota has emerged as a critical contributor to intestinal inflammatory diseases, however most studies have focused on bacteria despite the presence of fungi. Several clinical and experimental observations have shown that the mycobiota are important for the course of inflammatory bowel disease (IBD). Crohn ’s disease patients have higher levels of Candida tropicalis compared to healthy counterparts, and majority of the fungal species in a DSS–induced colitis murine model is comprised of C.

Source: Gastroenterology - February 1, 2019 Category: Gastroenterology Authors: Kristine-Ann Buela, Carlo De Salvo, Hannah Havran, Christopher Hager, Clifford Ivester, Mahmoud Ghannoum, Theresa Pizarro Tags: Innate and Mucosal Immunology and Immunity Source Type: research