Update on the diagnosis and management of acute heart failure

Purpose of review To highlight the advances in the diagnosis and management of acute heart failure (AHF) from recent clinical trials and observational studies. Recent findings We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the diagnosis of AHF. In addition, we summarize the evidence for novel pharmacological therapies including: serelaxin, ularitide, clevidipine, urocortins, BMS-986231, TRB027, vericiguat, omecamtiv, and torsemide. Finally, we explore the evidence behind the use of novel management algorithms. Summary Despite many advances in understanding the pathophysiology of AHF, there is currently insufficient evidence to suggest changes to standards of care.
Source: Current Opinion in Cardiology - Category: Cardiology Tags: HEART FAILURE: Edited by Haissam Haddad Source Type: research