A Peripherally Restricted P2Y12 Receptor Antagonist Altered Rat Tumor Incidences with No Human Relevance: Mode of Action Consistent with Dopamine Agonism

In conclusion Ticagrelor increased uterine tumors in the rat carcinogenesis study by a MOA consistent with reduced dopamine inhibition of prolactin, which is not a patient safety risk.
Source: Toxicology Reports - Category: Toxicology Source Type: research