Ameliorative effect of Phosphodiesterase-5 inhibitor in Rat model of Vascular Dementia.

Ameliorative effect of Phosphodiesterase-5 inhibitor in Rat model of Vascular Dementia. Curr Neurovasc Res. 2019 Jan 30;: Authors: Bhatia P, Singh N Abstract Cerebral hypoperfusion has been associated with increased risk of vascular dementia (VaD). The present study investigates the potential of Tadalafil, a phosphodiesterase-5 inhibitor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced VaD. Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. Morris water-maze (MWM) test (7thday onwards post-surgery) was employed to assess learning and memory whereby escape latency time, time spent in target quadrant, Path length and average swim speed taken as important parameters. Endothelial dysfunction was assessed in isolated aorta by observing endothelial dependent acetylcholine induced vasorelaxations and levels of serum nitrite. Various biochemical and histopathological estimations were also performed. BCCAo produced significant impairment in endothelium dependent vasorelaxations and decrease in serum nitrite levels indicating endothelial dysfunction. Further these animals performed poorly on MWM, depicting impairment of learning and memory. There was a significant rise in brain oxidative stress level (indicated by increase in brain thiobarbituric acid reactive species and decrease in reduced glutathione levels). An increase in brain acetylcholinesterase activity was also observed. In additio...
Source: Current Neurovascular Research - Category: Neurology Authors: Tags: Curr Neurovasc Res Source Type: research