Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.

CONCLUSIONS: Shorter LTLs in CAD patients with previously suffered MI may indicate telomere attrition as part of its pathophysiology in men. The inverse association between LTLs and age exclusively in women underpins the previously reported decline in attrition rate in men with increasing age. As elevated GDF11 and SIRT1 along with attenuated pro-inflammatory cytokines seem to positively affect LTL in women, we hypothesize a potential sex-dimorphism in LTL regulation, which may implicate sex- adjusted health-preventive therapies.
PMID: 30684534 [PubMed - as supplied by publisher]

Source: Experimental Gerontology - January 23, 2019 Category: Geriatrics Authors: Opstad TB, Kalstad AA, Pettersen AÅ, Arnesen H, Seljeflot I Tags: Exp Gerontol Source Type: research