The prognostic role of Gender ‐Age‐Physiology system in idiopathic pulmonary fibrosis patients treated with pirfenidone

Conclusion68 IPF patients were enrolled in the study. The median follow ‐up was 2.4 years (range 0.1‐7.4 years). A total of 22 deaths as first event (32%) and of 10 lung transplantation (15%) were recorded. The cumulative incidence of mortality at 1, 2, and 3 years was 10.4%, 22.4%, and 38.4%, respectively. The differences between the predicted and observed mortalit y were not significant for the GAP index while the observed mortality become comparable to that predicted by the GAP calculator only in the third year of follow up. The C‐index for the GAP index was 0.74 (95% CI 0.57‐0.93) while the C‐statistic value for the GAP calculator was 0.77 (95% CI 0.5 9‐0.95).This is the first study that investigate the reliability of the GAP system as a predictive tool in the era of antifibrotic therapies in a national real life IPF population. In our cohort the GAP system showed a good discrimination index. Additional studies would be evaluable to determine the impact of treatment on model performance.This article is protected by copyright. All rights reserved.

Source: The Clinical Respiratory Journal - January 23, 2019 Category: Respiratory Medicine Authors: Sergio Harari, Antonella Caminati, Marco Confalonieri, Venerino Poletti, Carlo Vancheri, Alberto Pesci, Rogliani Paola, Fabrizio Luppi, Carlo Agostini, Paola Rottoli, Alessandro Sanduzzi Zamparelli, Alfredo Sebastiani, Rossana Della Porta, Fr Tags: Original Article Source Type: research