Focused ultrasound as a potential means of facilitated exosome delivery to brodmann area 25 in the treatment of refractory depression

This study intended to provide clinical relief for patients with depression by increasing localized perfusion to Brodmann area 25 (BA25) in combination with intravenous exosome delivery. Here, we detail two case studies in which neuro-navigated ultrasound was used to aid exosomal delivery to the subgenual cingulate (SGC, BA25). The patients were both diagnosed with severe treatment-resistant Major Depressive Disorder (MDD) and had previously undergone transcranial magnetic stimulation (TMS) and intensive regimens of antidepressant medication with no symptom relief.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research