Depressive Symptomatology, Racial Discrimination Experience and MRI Brain Tissue Volumes: The CARDIA Study.

Depressive Symptomatology, Racial Discrimination Experience and MRI Brain Tissue Volumes: The CARDIA Study. Am J Epidemiol. 2019 Jan 18;: Authors: Meyer CS, Schreiner PJ, Lim K, Battapady H, Launer LJ Abstract Not much is known about brain structural change in younger populations and minorities. The cross-sectional relationship between depressive symptomatology and racial discrimination with structural measures of brain tissue volume was investigated using magnetic resonance images for 710 participants in the CARDIA Study in 2010. Those reporting depressive symptoms and racial discrimination had lower total brain matter tissue volume compared to those who reported neither (-8.8 mL; 95% CI: -16.4, -1.2), compared to those with depressive symptoms only (-10.9 mL; 95% CI: -20.4, -1.4), and compared to those with racial discrimination only (-8.6 mL; 95% CI: -16.5, -0.8). Similar results were found for total normal white matter tissue. There were 103% higher odds (OR = 2.03; 95% CI: 1.32, 3.14) of being in the highest quartile of white matter hyperintensities in those with depressive symptoms only compared to those without. While tests for interaction by race were not statistically significant, sensitivity analyses stratifying by race found inverse associations only among Black participants with combined depressive symptomatology and racial discrimination for total brain matter and total white matter tissue volumes, and positive asso...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research