Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop

Publication date: Available online 15 January 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Corie A. Ellison, Karen L. Blackburn, Paul L. Carmichael, Harvey J. Clewell, Mark T.D. Cronin, Bertrand Desprez, Sylvia E. Escher, Steve S. Ferguson, Sébastien Grégoire, Nicola J. Hewitt, Heli M. Hollnagel, Martina Klaric, Atish Patel, Sabrina Salhi, Andreas Schepky, Barbara G. Schmitt, John F. Wambaugh, Andrew WorthAbstractThe Threshold of Toxicological Concern (TTC) is an important risk assessment tool which establishes acceptable low-level exposure values to be applied to chemicals with limited toxicological data. One of the logical next steps in the continued evolution of TTC is to develop this concept further so that it is representative of internal exposures (TTC based on plasma concentration). An internal TTC (iTTC) would provide threshold values that could be utilized in exposure-based safety assessments. As part of a Cosmetics Europe (CosEu) research program, CosEu has initiated a project that is working towards the development of iTTCs that can be used for the human safety assessment. Knowing that the development of an iTTC is an ambitious and broad-spanning topic, CosEu organized a Working Group comprised a balance of multiple stakeholders (cosmetics and chemical industries, the EPA and JRC and academia) with relevant experience and expertise and workshop to critically evaluate the requirements to establish an iTTC. Outcomes from the workshop included an eva...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research