Pre-transplant ALBI Grade 3 Is Associated with Increased Mortality After Liver Transplantation

This study aimed to evaluate ALBI score as a prognostic factor in LT.MethodsThis  is a single-center analysis of patients undergoing LT between October 2001 and June 2017. Primary endpoint was overall post-LT mortality. Secondary endpoint was 90-day mortality.ResultsOf all 301 patients included in this study, 185 (61.5%) were males. The  median age was 54.1 ± 11.3 years. Univariate and multivariate analysis revealed that ALBI grade 3 (HR 1.836, 95% CI 1.154–2.921,p  =  0.010), low serum albumin (HR 0.628, 95% CI 0.441–0.893,p  =  0.010), black race (HR 2.431, 95% CI 1.160–5.092,p  =  0.019), and elevated body mass index (HR 1.061, 95% CI 1.022–1.102,p  =  0.002) all were associated with decreased overall survival following LT. Patients with both ALBI grade 3 (n = 25) and calculated MELD score ≥ 25 had the lowest overall survival (p  <  0.001).DiscussionALBI grade 3 was related to lower post-LT survival and can be utilized as a tool for risk stratification in LT.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research