Omega-3 Fatty Acid and Cardiovascular Outcomes: Insights From Recent Clinical Trials

AbstractPurpose of ReviewOmega-3 fatty acids ( ω-3 FA) are among the most well-recognized health supplements but their cardiovascular benefits have long been controversial owing to inconsistent results from previous cardiovascular outcomes trials (CVOT). In this article, we provide a short review of existing literature followed by recent random ized clinical trial data, with a discussion of the potential clinical implications of these new findings.Recent FindingsData from the randomized, controlled trial REDUCE-IT, when viewed within the context of other recently published trials ASCEND and VITAL, add to a growing body of evidence on the use of ω-3 FA therapies in the treatment of atherosclerotic cardiovascular disease (ASCVD).SummaryGiven the different formulations, dosages, and patient populations studied, CVOTs of ω-3 FA have provided valuable insight into the use of these agents in cardioprotection. Current data suggest that higher dosages of pure eicosapentaenoic acid ω-3 FA formulations provide additional benefit in reduction of ASCVD events.

Source: Current Atherosclerosis Reports - January 10, 2019 Category: Cardiology Source Type: research