Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome

ConclusionsOur study provides novel insights into the neural substrates of appetite control in a genetically-mediated cause of obesity. The presence of significant cortical changes further indicates that PWS patients consciously process disgusting stimuli, but the virtual absence of response in deep, limbic structures suggests that disgusting signals do not adequately reach the primary brain system for the appetite control.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research