Mitochondria and familial predisposition to breast cancer.

Mitochondria and familial predisposition to breast cancer. Curr Genomics. 2013 May;14(3):195-203 Authors: Weigl S, Paradiso A, Tommasi S Abstract Mitochondrial genome and functional alterations are related to various diseases including cancer. In all cases, the role of these organelles is associated with defects in oxidative energy metabolism and control of tumor-induced oxidative stress. The present study examines the involvement of mitochondrial DNA in cancer and in particular in breast cancer. Furthermore, since mitochondrial DNA is maternally inherited, hereditary breast cancer has been focused on. PMID: 24179442 [PubMed]
Source: Current Genomics - Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research