Crude Inactivated Influenza A Virus Adjuvated with a Bispecific Antibody Complex Targeting Chicken CD40 and AIV M2e Confers Protection Against Lethal HPAI Challenge in Chickens.

Crude Inactivated Influenza A Virus Adjuvated with a Bispecific Antibody Complex Targeting Chicken CD40 and AIV M2e Confers Protection Against Lethal HPAI Challenge in Chickens. Monoclon Antib Immunodiagn Immunother. 2018 Dec;37(6):245-251 Authors: Vuong CN, Chou WK, Briggs W, Faulkner O, Wolfenden A, Jonas M, Kapczynski DR, Hargis BM, Bielke LR, Berghman LR Abstract In vivo targeting an immunogen to the CD40 receptor expressed on professional antigen-presenting cells (APCs) dramatically enhances speed, magnitude, and quality of the immune response. Our previous evaluation of this strategy in poultry was limited to immunogenicity studies using CD40-targeted synthetic peptides, which demonstrated significant antigen-specific serum IgG and tracheal IgA levels
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research

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Abstract In January 2020, the subclade 2.3.4.4h of highly pathogenic avian influenza (H5N6) virus infected migratory whooper swans and mute swans in Xinjiang, western China. The virus is lethal to chickens and ducks but has low pathogenicity in mice. Antigenically, this subclade is similar to the H5N1 vaccine seed virus Re-11. PMID: 33030424 [PubMed - as supplied by publisher]
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Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
Publication date: Available online 18 September 2020Source: Veterinary MicrobiologyAuthor(s): Jiao Hu, Ming Kong, Zhu Cui, Zhao Gao, Chunxi Ma, Zenglei Hu, Xinan Jiao, Xiufan Liu
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