The use of Fionet technology for external quality control of malaria rapid diagnostic tests and monitoring health workers' performance in rural military health facilities in Tanzania.

CONCLUSION: Fionet technology enabled remote monitoring of RDT quality issues, identifying reasons contributing to laboratory personnel making errors and provided a rapid method to implement corrective actions at remote sites to improve malaria diagnosis and consequently improved health care management of febrile patients infected with malaria. PMID: 30589853 [PubMed - in process]
Source: Rural Remote Health - Category: Rural Health Authors: Tags: PLoS One Source Type: research

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[Citizen] Dar es Salaam -Global health financier, Global Fund (GF), has embarked on a move to trace a Sh2.77 billion fund for delivery of antimalarial drugs that are believed to been over-supplied in Tanzanian health facilities, if records are anything to go by.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[Centre 4s] The G 5 Sahel and France Summit should be held in Nouakchott, Mauritania, on February 24. It should go to the actual issues and deal with the most urgent, in order to give hope to the Sahel populations. And probably also to their allies.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
We examined the association between the EPCR rs867186-GG genotype and the protection against cerebral malaria. Peripheral blood samples were collected from 47 malaria patients and 34 healthy individuals from a study conducted from 2004 to 2007 at the NSCB Medical College Hospital in India. CM and malaria-associated complications were defined based on WHO criteria. Genomic DNA was isolated from the peripheral blood mononuclear cells. Primer sequences were designed to contain rs867186 of the PROCR gene (NM 006404) and were used to amplify a 660 bp product as described before. PCR products were purified, and DNA sequences wer...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Authors: Lambraño J, Curtidor H, Avendaño C, Díaz-Arévalo D, Roa L, Vanegas M, Patarroyo ME, Patarroyo MA Abstract Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. The disease cost the lives of more than 400,000 people, mainly in Africa. In spite of great efforts aimed at developing better prevention (i.e., a highly effective vaccine), diagnosis, and treatment methods for malaria, no efficient solution to this disease ...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Publication date: Available online 22 February 2020Source: Microbes and InfectionAuthor(s): Luiza Carvalho Mourão, Camila Maia Pantuzzo Medeiros, Gustavo Pereira Cardoso-Oliveira, Paula Magda da Silva Roma, Jamila da Silva Sultane Aboobacar, Beatriz Carolina Medeiros Rodrigues, Ubirajara Agero, Cor Jesus Fernandes Fontes, Érika Martins BragaAbstractAutoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here w...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Publication date: Available online 21 February 2020Source: Journal of EthnopharmacologyAuthor(s): I.C. Ezenyi, V. Verma, S. Singh, S.E. Okhale, B. AdzuAbstractEthnopharmacological relevanceSub – Saharan Africa has a high malaria burden and Nigeria accounts for majority of malaria cases worldwide. The aim of this study was to evaluate selected plants extracts used against malaria in Nigeria for antiplasmodial activity.Materials and methodsAn ethnomedicinal based - approach by literature survey was used to identify plants used in the study. The parts of the plant used were collected and extracted with 70% v/v ethanol; ...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Contributors : Maria Toro-Moreno ; Kayla SylvesterSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Plasmodium bergheiThe apicomplexan parasites Plasmodium spp. are the causative agents of malaria, a disease that poses a significant global health burden. Plasmodium spp. initiate infection of the human host by transforming and replicating within hepatocytes. Yet, despite the liver stage being a critical step during infection, most transcriptomic studies have focused on more technically accessible stages of the Plasmodium life cycle, limiting our ability to target these parasites to pr...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Plasmodium berghei Source Type: research
Abstract Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. 1,3,4-Thiadiazoles have been widely studied for medical applications. The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scienti...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Condition:   Malaria,Falciparum Interventions:   Biological: PfSPZ Challenge;   Drug: Sulfadoxine-Pyrimethamine;   Drug: Piperaquine;   Drug: Artemether lumefantrine;   Drug: Primaquine Sponsors:   University of Oxford;   KEMRI-Wellcome Trust Collaborative Research Program;   Sanaria Inc.;   University Hospital Heidelberg;   Kenya Medical Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article will highlight the strategies used to move this critical antimalarial drug through the development pipeline. PMID: 32074317 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
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