Error in Results

In the Editorial titled “Prevalence and Severity of Alzheimer Disease in Individuals With Down Syndrome,” published online November 19, 2018, a typographical error was corrected in the sentence in the third paragraph that includes the phrase “late-onset epilepsy increased mortality risk in individuals with DS and dem entia by 10-fold.” The phrase “in individuals with DS and dementia” was changed to “in individuals with DS without dementia.”
Source: JAMA Neurology - Category: Neurology Source Type: research

Related Links:

Publication date: Available online 16 November 2019Source: Epilepsy &BehaviorAuthor(s): Jane Hanna, Rosemary Panelli
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Conclusions and ImplicationsAlthough group differences were not found when considering parent-reported sleep problems, more frequent sleep problems were positively associated with increased forgetting by children with DS relative to those who were TD. Although future experimental work is needed to determine causality, these results suggest that improved sleep in children with DS might reduce forgetting, ultimately improving long-term recall memory.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: Available online 16 November 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Hanie Yavarpour-Bali, Maryam Ghasemi-Kasman, Amir ShojaeiAbstractGlial activation is a common pathological process of the central nervous system (CNS) in disorders such as Alzheimer's disease (AD). Several approaches have been used to reduce the number of activated astrocytes and microglia in damaged areas. In recent years, various kinds of fully differentiated cells have been successfully reprogrammed to a desired type of cell in lesion areas. Interestingly, internal glial cells, including as...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Sofie Mathiassen’s images win a prize from group raising awareness about the disease.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Discussion New-onset epilepsy seems to occur early in the course of dementia in DS patients. Patients generally respond to treatment. A great burden of neuropsychiatric symptoms is seen. Future studies need to explore the relationship between β-amyloid accumulation and epileptiform activity and attend to the care and needs of DS patients with dementia and seizures.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Purpose of review: Alzheimer's disease is most likely universal in older individuals with Down syndrome, due to having three copies of the amyloid precursor protein gene, resulting in amyloid-beta plaque deposition. Down syndrome is an important population in which to consider clinical trials of treatments to prevent or delay the development of dementia. However, assessment of subtler cognitive changes is challenging due to the presence of intellectual disability. Recent findings: Recent research confirmed that older adults with Down syndrome often present with cognitive decline: more than 80% may experience dementia by a...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: NEURODEVELOPMENTAL DISORDERS: Edited by James C. Harris Source Type: research
DISCUSSION: New-onset epilepsy seems to occur early in the course of dementia in DS patients. Patients generally respond to treatment. A great burden of neuropsychiatric symptoms is seen. Future studies need to explore the relationship between β-amyloid accumulation and epileptiform activity and attend to the care and needs of DS patients with dementia and seizures. PMID: 28109983 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Abstract PURPOSE OF REVIEW: Alzheimer's disease is most likely universal in older individuals with Down syndrome, due to having three copies of the amyloid precursor protein gene, resulting in amyloid-beta plaque deposition. Down syndrome is an important population in which to consider clinical trials of treatments to prevent or delay the development of dementia. However, assessment of subtler cognitive changes is challenging due to the presence of intellectual disability. RECENT FINDINGS: Recent research confirmed that older adults with Down syndrome often present with cognitive decline: more than 80% may ex...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Opin Psychiatry Source Type: research
CONCLUSIONS: New onset epilepsy seems to occur early in the course of dementia in DS patients. It is unclear if epilepsy has a role in dementia progression. Treatment response was generally good except for epileptic myoclonus. Future studies are needed to study patients with DS and dementia, with and without epilepsy and investigate the interplay between Alzheimer’s dementia pathology.Disclosure: Dr. Gholipour has nothing to disclose. Dr. Sarkis has nothing to disclose. Dr. El-Chemali has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Epilepsy/Clinical Neurophysiology (EEG): Clinical Epilepsy Source Type: research
More News: Alzheimer's | Brain | Dementia | Down's Syndrome | Epilepsy | Neurology