The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling

Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is one of the leading lethal malignancies globally. The highest incidence of HCC is in East and South-East Asia and Northern and Western Africa[1]. However, the incidence of liver cancer, including HCC, has risen in areas with historically low rates, for instance, Western Europe, Northern America and parts of Oceania. Infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) as well as metabolic disorders is etiologically responsible for HCC[2].

Source: Journal of Hepatology - December 21, 2018 Category: Gastroenterology Authors: Jiayi Wu, Pingping Zhu, Tiankun Lu, Ying Du, Yanying Wang, Luyun He, Buqing Ye, Benyu Liu, Liuliu Yang, Jing Wang, Yang Gu, Jie Lan, Yajing Hao, Lei He, Zusen Fan Source Type: research