Abstract 2079: EpHA2 is an essential driver of invasion and a novel target in KRAS mutant colorectal cancer

Conclusion Using our novel comprehensive systems biology approach we have identified novel KRAS synthetic lethal targets and pathways. Combining these findings with targets which are effective against our pre-clinical adjuvant models we have identified EpHA2 as a key driver of invasion and migration and a synthetically lethal target in KRASMT CRC. In addition, we show that EpHA2 is a poor prognostic marker and an important novel target for KRASMT CRC tumors in both the adjuvant and advanced disease setting. Citation Format: Philip D. Dunne, Darragh G. McArt, Jaine K. Blayney, Sonali Dasgupta, Manuel Salto-Tellez, Patrick G. Johnston, Sandra Van Schaeybroeck. EpHA2 is an essential driver of invasion and a novel target in KRAS mutant colorectal cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2079. doi:10.1158/1538-7445.AM2014-2079
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Tumor Biology Source Type: research