The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice.

Conclusion: Co-inhibiting the expressions of PD-1 and CTLA-4 can effectively suppress the growth of H22 hepatoma and promote the apoptosis of tumor cells in mice. Blocking PD-1 and CTLA-4 can improve the vitality of T cells, and improve the immune environment and response.
PMID: 30564277 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - December 20, 2018 Category: Biochemistry Authors: Liang L, Ge K, Zhang F, Ge Y Tags: Cell Mol Biol Lett Source Type: research