CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation

ConclusionEquivalent therapeutic effects were observed between CP-25-combination groups and high-dose MTX/LEF groups. CP-25 inhibited p-ERK by reducing the membrane expression of GRK2 in FLS from AA rats.Graphical abstractFigure. Mechanism of CP-25 combined with MTX/LEF to ameliorate AA ratsIn the one hand, CP-25 alone and in combination blocked the activation of P38, ERK, and JNK. CP-25 combined with MTX/LEF exerts synergistic effects to inhibit inflammation of AA rats by inhibiting the MAPK pathway. In the other hand, CP-25 inhibited GRK2 translocation in AA rats which further restored the inhibition of GRK2 on p-ERK. CP-25 synergized with MTX/LEF through GRK2-induced inhibition of p-ERK, thereby suppressing inflammation in AA rats.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research