Vitamin E TPGS emulsified vinorelbine bitartrate loaded solid lipid nanoparticles (SLN)

(Bentham Science Publishers) Vinorelbine bitartrate (VRL), a semi synthetic vinca alkaloid approved for breast cancer, has been proven to be beneficial as first line and subsequent therapies. However, its hydrophilic and thermo labile nature provides hindrance to oral clinical translation. The current work focused on the application of DOE a modern statistical optimization tool for the development and optimization of a solid lipid nanoparticle (SLN) formulation that can encapsulate hydrophilic and thermolabile Vinorelbine bitartrate (VRL) to a maximum extent without compromising integrity and anticancer activity of the drug.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news