The neural basis of fatigue in multiple sclerosis: A multimodal MRI approach

Conclusions
In this study, fatigue was associated with widespread NAWM damage but not with lesion load or GM atrophy. Functional disconnection, caused by diffuse microstructural WM damage, might be the main neural basis of fatigue in MS.

Source: Neurology Clinical Practice - December 10, 2018 Category: Neurology Authors: Novo, A. M., Batista, S., Alves, C., dAlmeida, O. C., Marques, I. B., Macario, C., Santana, I., Sousa, L., Castelo-Branco, M., Cunha, L. Tags: MRI, Multiple sclerosis Research Source Type: research