HEAL Initiative: Sleep and Circadian-Dependent Mechanisms Contributing to Opiate Use Disorder (OUD) and Response to Medication Assisted Treatment (MAT) (U01 Clinical Trial Optional)

Funding Opportunity RFA-HL-19-029 from the NIH Guide for Grants and Contracts. This FOA invites clinical studies to elucidate sleep and circadian mechanisms that contribute to the risk of opiate use disorder (OUD), the pathobiology of opiate withdrawal, and that influence the response to medication-assisted treatment (MAT). Studies are needed to apply advances in understanding sleep and circadian biology to improving our understanding of OUD, the directionality of sleep and OUD interactions, and the opportunities to improve therapy and outcome. Multi-disciplinary, multiple-investigator teams combining expertise in clinical research, mechanisms of sleep and circadian rhythms, neurobiology of OUD, and neuropharmacology of MAT are strongly encouraged. This FOA is only open to the study of OUD relevant mechanisms and pathobiology. Evaluating the efficacy of one or more interventions without a rigorous mechanistic study design should not be proposed.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding